Bronsted Acid Mediated Facile Greener Multicomponent Synthesis of 2,4-Diaryl-quinoline Derivatives in Water

  • Lucas Michelão Martins Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
  • Vitor Fernandes Moreno Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
  • Ilana Sganzerla Rosário Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
  • Carlos Frederico de Oliveira Graeff Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
  • Luiz Carlos da Silva Filho Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
Keywords: Acid catalyst; Green synthesis; Nitrogen heterocycles; Quinoline

Abstract

Quinolines are an important class of natural and synthetic products, with several biological activity and applications in medicine and electronics. In this work we present a greener method of synthesis of 2,4-diaryl-quinoline derivatives by an easy one-pot multicomponent reaction between aniline derivatives, aldehyde derivatives and phenylacetylene in water, with hydrochloric acid as promoter. With this method we could synthesize several compounds with good yield and reaction time, including new alkylamino-containing 2,4-diaryl-quinoline derivatives that could not be synthesized with niobium pentachloride catalyst in similar conditions.

DOI: http://dx.doi.org/10.17807/orbital.v14i1.1689

Published
2022-04-07
How to Cite
Martins, L. M., Moreno, V. F., Rosário, I. S., Graeff, C. F. de O., & da Silva Filho, L. C. (2022). Bronsted Acid Mediated Facile Greener Multicomponent Synthesis of 2,4-Diaryl-quinoline Derivatives in Water. Orbital: The Electronic Journal of Chemistry, 14(1), 1-9. Retrieved from https://periodicos.ufms.br/index.php/orbital/article/view/15493