Orbital - Vol. 14 No. 1 - January-March 2022
FULL PAPERS

Bronsted Acid Mediated Facile Greener Multicomponent Synthesis of 2,4-Diaryl-quinoline Derivatives in Water

Lucas Michelão Martins
Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
Vitor Fernandes Moreno
Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
Ilana Sganzerla Rosário
Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
Carlos Frederico de Oliveira Graeff
Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
Luiz Carlos da Silva Filho
Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
Published April 7, 2022
Keywords
  • Acid catalyst; Green synthesis; Nitrogen heterocycles; Quinoline
How to Cite
(1)
Martins, L. M.; Moreno, V. F.; Rosário, I. S.; Graeff, C. F. de O.; da Silva Filho, L. C. Bronsted Acid Mediated Facile Greener Multicomponent Synthesis of 2,4-Diaryl-Quinoline Derivatives in Water. Orbital: Electron. J. Chem. 2022, 14, 1-9.

Abstract

Quinolines are an important class of natural and synthetic products, with several biological activity and applications in medicine and electronics. In this work we present a greener method of synthesis of 2,4-diaryl-quinoline derivatives by an easy one-pot multicomponent reaction between aniline derivatives, aldehyde derivatives and phenylacetylene in water, with hydrochloric acid as promoter. With this method we could synthesize several compounds with good yield and reaction time, including new alkylamino-containing 2,4-diaryl-quinoline derivatives that could not be synthesized with niobium pentachloride catalyst in similar conditions.

DOI: http://dx.doi.org/10.17807/orbital.v14i1.1689