Orbital - Vol. 9 No. 1 - January - March 2017
FULL PAPERS

Anticariogenic and Antimycobacterial Activities of the Essential Oil of Siparuna guianensis Aublet (Siparunaceae)

Daiana Caetano de Melo
Instituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais – Campus Pouso Alegre
Mayker Lazaro Dantas Miranda
Instituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais – Campus Pouso Alegre
Walnir Gomes Ferreira Júnior
Instituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais – Campus Machado
Priscila Mileide de Andrade
Instituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais – Campus Pouso Alegre
Ana Elisa Teixeira Alcoba
Instituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais – Campus Pouso Alegre
Thayná de Souza Silva
Centro de Pesquisa em Ciências Exatas e Tecnologia, Universidade de Franca
Cristiane de Melo Cazal
Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais – Campus Barbacena
Carlos Henrique Gomes Martins
Centro de Pesquisa em Ciências Exatas e Tecnologia, Universidade de Franca
Published March 31, 2017
Keywords
  • antimycobacterial activity,
  • cariogenic bacteria,
  • essential oil,
  • Mycobacterium tuberculosis,
  • Siparuna guianensis,
  • Streptococcus mutans
  • ...More
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How to Cite
(1)
de Melo, D. C.; Miranda, M. L. D.; Ferreira Júnior, W. G.; de Andrade, P. M.; Alcoba, A. E. T.; Silva, T. de S.; Cazal, C. de M.; Martins, C. H. G. Anticariogenic and Antimycobacterial Activities of the Essential Oil of Siparuna Guianensis Aublet (Siparunaceae). Orbital: Electron. J. Chem. 2017, 9, 55-60.

Abstract

Siparuna guianensis is a Brazilian plant with extensive ethnobotanical indication and identified as one of the priority species that should be preserved in the Brazilian Cerrado. This work aimed to investigate the chemical composition and the antibacterial effects of the essential oil from leaves of S. guianensis (SG-EO) grown in southeastern Brazil against a representative panel of oral pathogens and mycobacteria. Anticariogenic and antimycobacterial activities of SG-EO were evaluated in terms of their minimum inhibitory concentrations (MICs). The essential oil from leaves of S. guianensis was analyzed by gas chromatography coupled to mass spectrometry (GC-MS). Forty one compounds were identified, accounting for 92.7 % of the SG-EO composition. E,E-farnesol (18.0 %), β-myrcene (16.0 %), germacrene-D (10.0 %) and siparunone (14.6 %) were the major SG-EO constituents. SG-EO showed the strongest anticariogenic activity against the aerobic bacterium Streptococcus mutans (MIC of 50 µg/mL). SG-EO was also evaluated for its antimycobacterial activity, and showed MIC values of 250 µg/mL against Mycobacterium avium and 500 µg/mL against M. tuberculosis and M. kansasii. These results imply that S. guianensis may be a new alternative source of substances of medicinal interest. This is the first report of anticariogenic and antimycobacterial activities of essential oil of S. guianensis.

DOI: http://dx.doi.org/10.17807/orbital.v0i0.930