USE OF PLANTS TO TREAT ANXIETY IN THE CONTEXT OF POPULAR KNOWLEDGE AND ANXIOLYTIC PROPERTIES: AN INTEGRATIVE REVIEW
Keywords:
Medicinal plants, anxiety, anxiolytic properties, popular knowledge.
Abstract
Introduction: The predominant treatments for anxiety disorders are antidepressants, benzodiazepines and hypnotics, but pharmacological treatment is still accompanied by adverse effects, high dropout rate, dependence and ineffective therapeutic response. Some choose to employ an adjuvant or substitute treatment for pharmacological therapy, highlighting phytotherapy in this context.
Objective: To identify plants used to treat anxiety in the context of popular health practices.
Method: Integrative Literature Review. The research was conducted in the Scopus and Web of Sciences databases, through the association of the terms “Anxiety”, “Traditional Medicine” and “Medicinal Plants. The articles were categorized and organized according to the species mentioned, the parts used, the traditional preparations mentioned and whether there is evidence in the scientific literature of pharmacological properties with an effect on the CNS.
Results: 3 studies were included in the final sample. 54 species were mentioned and only 9 plants did not show anxiolytic, sedative or hypnotic activity, with central nervous system depression reported in the literature.
Conclusion: It was observed that there are records about plants for the treatment of anxiety by traditional communities, as well as studies that point to anxiolytic properties for the vast majority of identified species, showing the consonance, often observed, between popular knowledge and biomedical knowledge.
References
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https://www.researchgate.net/publication/315481695_Transtornos_mentais_comuns_nos_Cuidados_de_Saude_Primarios_Um_estudo_de_revisao
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6. Goyatá SLT, Avelino CCV, Santos SVM, Souza Jr DI, Gurgel MDSL, Terra FS. Effects from acupuncture in treating anxiety: integrative review. Revista Brasileira de Enfermagem, 2016; 69(3):564-71. Disponível em : https://www.scielo.br/j/reben/a/nFTpYKy5K4GY9JRXZ7FvcRc/?lang=en&format=pdf
7. Karadag E, Samancioglu S, Ozden D, Bakir E. Effects of aromatherapy on sleep quality and anxiety of patients. Nursing Critical Care, 2017; 22(2):105-112. Disponível em : https://pubmed.ncbi.nlm.nih.gov/26211735/
8. Ahmed HM. Ethnopharmacobotanical study on the medicinal plants used by herbalists in Sulaymaniyah Province, Kurdistan, Iraq. Journal of ethnobiology and ethnomedicine, 2016; 12:8. Disponível em : https://ethnobiomed.biomedcentral.com/articles/10.1186/s13002-016-0081-3
9. Brasil AX, Barbosa MO, Lemos ICS, Lima CINF, Delmondes GA, Lacerda GM, et al. Preference analysis between the use of drugs and plants in pain management in a quilombola community of the state of Ceará, Brazil. Journal of Medicinal Plants Research, 2017; 11(48): 770-777. Disponível em : https://academicjournals.org/journal/JMPR/article-full-text/6903A6867051
10. Mata R, Figueroa M, Navarrete A, Rivero-Cruz I. Chemistry and Biology of Selected Mexican Medicinal Plants. Progress in the Chemistry of Organic Natural Products, 2019; 108:1-142. Disponível em : https://pubmed.ncbi.nlm.nih.gov/30924013/
11. Hopia H, Latvala E, Liimatainen L. Reviewing The Methodology Of An Integrative Review. Scandinavian Journal Of Caring Sciences, 2016; 30(4):662-669. Disponível em : https://pubmed.ncbi.nlm.nih.gov/30924013/
12. Antonio RL, Kozasa EH, Galduróz JCF, Dorjee Y, Kalsang T, Norbu T, et al. Formulas Used by Tibetan Doctors at Men‐Tsee‐Khang in India for the Treatment of Neuropsychiatric Disorders and Their Correlation with Pharmacological Data. Phytotherapy Research, 2013; 27(4):552-563. Disponível em : https://pubmed.ncbi.nlm.nih.gov/22674653/
13. Peeke PM, Frishett S. The role of complementary and alternative therapies in women's mental health. Primary Care, 2002; 29(1):183-197. Disponível em : https://pubmed.ncbi.nlm.nih.gov/11856666/
14. Kumar V, Jaiswal AK, Singh PN, Bhattacharya SK. Anxiolytic activity of Indian Hypericum perforatum Linn: an experimental study. Indian journal of experimental biology, 2000; 38(1):36-41. Disponível em : https://pubmed.ncbi.nlm.nih.gov/11233082/
15. Van Wyk BE, Albrecht C. A review of the taxonomy, ethnobotany, chemistry and pharmacology of Sutherlandia frutescens (Fabaceae). Journal of ethnopharmacology, 2008; 119(3):620-629. Disponível em : https://pubmed.ncbi.nlm.nih.gov/18761068/
16. Smith C, Van Vuuren MJ. Central and peripheral effects of Sutherlandia frutescens on the response to acute psychological stress. Experimental biology and medicine, 2014; 239(1):123-128.
Disponível em : https://journals.sagepub.com/doi/abs/10.1177/1535370213510253?journalCode=ebmb
17. Stafford GI, Jäger AK, Van Staden J. Activity of traditional South African sedative and potentially CNS-acting plants in the GABA-benzodiazepine receptor assay. Journal of ethnopharmacology,2005;100(1):210-215. Disponível em : https://pubmed.ncbi.nlm.nih.gov/16054530/
18. García GP, López MF, Rubio G, Martín AB, Alamo C. Phytotherapy and psychiatry: Bibliometric study of the scientific literature from the last 20 years. Phytomedicine 2008; 15(8):566-576.doi:10.1016/j.phymed.2008.04.014. Disponível em: https://pubmed.ncbi.nlm.nih.gov/18583120/
19. Sarris J, La PE, Schweitzer I. Kava: a comprehensive review of efficacy, safety, and psychopharmacology. Australian and New Zealand Journal of Psychiatry, 2011; 45(1):27-35. Disponível em : https://pubmed.ncbi.nlm.nih.gov/21073405/
20. Xie W, Zhang X, Wang T, Hu J. Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L. (Luobuma): A review. J. ethnopharmacol. 2012 [citado 2017 Out 21];141(1):1-8. Disponível em : https://pubmed.ncbi.nlm.nih.gov/22421379/
21. Sahib NG, Anwar F, Gilani AH, Hamid AA, Saari N, Alkharfy KM. Coriander (Coriandrum sativum L.): A Potential Source of High-Value Components for Functional Foods and Nutraceuticals- A Review. Phytotherapy Research, 2013; 27(10):1439-1456. Disponível em : https://pubmed.ncbi.nlm.nih.gov/23281145/
22. Miroddi M, Calapai G, Navarra M, Minciullo PL, Gangemi S. Passiflora incarnata L.: Ethnopharmacology, clinical application, safety and evaluation of clinical trials. Journal of ethnopharmacology, 2013; 150(3):791-804. Disponível em : https://pubmed.ncbi.nlm.nih.gov/24140586/
23. Nair JJ, Staden J. Traditional usage, phytochemistry and pharmacology of the South African medicinal plant Boophone disticha (L.f.) Herb.(Amaryllidaceae). Journal of ethnopharmacology, 2014; 151(1):12-26. Disponível em : https://pubmed.ncbi.nlm.nih.gov/24211396/
24. Pote W, Musarira S, Chuma, D, Gadaga LL, Mwandiringana E, Tagwireyi D. Effects of a hydroethanolic extract of Boophone disticha bulb on anxiety-related behaviour in naive BALB/c mice. Journal of ethnopharmacology, 2018; 214:218-224. Disponível em : https://pubmed.ncbi.nlm.nih.gov/29223391/
25. Shakeri A, Sahebkar A, Javadi B. Melissa officinalis L. A review of its traditional uses, phytochemistry and pharmacology. Journal of ethnopharmacology, 2016; 188:204-228. Disponível em : https://pubmed.ncbi.nlm.nih.gov/27167460/
26. Luz DA, Pinheiro AM, Silva ML, Monteiro MC, Prediger RD, Ferraz Maia CS, et al. Ethnobotany, phytochemistry and neuropharmacological effects of Petiveria alliacea L. (Phytolaccaceae): A review. Journal of ethnopharmacology, 2014; 153(1):641-649. Disponível em : https://pubmed.ncbi.nlm.nih.gov/26944236/
27. Blainski A, Piccolo VK, Mello JC, de Oliveira RM. Dual effects of crude extracts obtained from Petiveria alliacea L. (Phytolaccaceae) on experimental anxiety in mice. Journal of ethnopharmacology, 2010; 128(2):541-4. Disponível em : https://pubmed.ncbi.nlm.nih.gov/20079419/
28. Nikfarjam M, Bahmani M, Soureshjani SH. Phytotherapy for anxiety in Iran: A review of the most important. Anti-anxiety medicinal plants. Journal of Chemical and Pharmaceutical Sciences, 2016; 9(3):1235-1241. Disponível em : https://www.researchgate.net/publication/309078491_Phytotherapy_for_anxiety_in_Iran_A_review_of_the_most_important_Anti-Anxiety_medicinal_plants
29. Alizadeh A, Aghaee Z. Essential oil constituents, phenolic content and antioxidant activity of Lavandula stricta Delile growing wild in southern Iran. Natural Products Research, 2016; 30(19):2253-7. Disponível em : https://pubmed.ncbi.nlm.nih.gov/26959122/
30. Aydin E, Hritcu L, Dogan G, Hayta S, Bagci E. The effects of inhaled Pimpinella peregrina essential oil on scopolamine-induced memory impairment, anxiety, and depression in laboratory rats. Molecular Neurobiology, 2016; 53(9):6557-6567. Disponível em : https://pubmed.ncbi.nlm.nih.gov/26768430/
31. Assad T, Khan RA. Effect of methanol extract of Trigonella foenum-graecum L. seeds on anxiety, sedation and motor coordination. Metabolic Brain Disease, 2017; 32(2):343-349. Disponível : https://pubmed.ncbi.nlm.nih.gov/27639708/
32. Sarris J, Mcintyre E, Camfield DA. Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. CNS Drugs, 2013; 27(4):301-19. Disponível em : https://pubmed.ncbi.nlm.nih.gov/23653088/
33. Vafaei AA, Miladi-Gorgi H, Moghimi HR, Ameri M. The effect of fruit Cassia fistula aqueous extract on sleeping time and the level of anxiety in mice. Journal of Gorgan University of Medical Sciences, 2011; 12(4):1-6. Disponível em : https://goums.ac.ir/journal/article-1-851-en.html
34. Boskabady MH, Shafei MN, Saberi Z, Amini S. Pharmacological effects of Rosa damascena. Iranian Journal of Basic Medicinal Science, 2011; 14(4):295–307. Disponível em : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586833/
35. Rubalcava CL, Camarena EE. Mexican medicinal plants with anxiolytic or antidepressant activity: Focus on preclinical research. Journal of ethnopharmacology, 2016; 186:377-391. Disponível em : https://pubmed.ncbi.nlm.nih.gov/27021688/
2. Murcho N, Pacheco E, Jesus SN. Transtornos mentais comuns nos Cuidados de Saúde Primários: Um estudo de revisão. Revista Portuguesa de Enfermagem em Saúde mental, 2016; 15:30-36.Disponível em :
https://www.researchgate.net/publication/315481695_Transtornos_mentais_comuns_nos_Cuidados_de_Saude_Primarios_Um_estudo_de_revisao
3. Dunsmoor JE, Paz R. Fear Generalization and Anxiety: Behavioral and Neural Mechanisms. Biological psychiatry, 2015; 78(5):336-343. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25981173/
4. Park SC, Kim YK. Anxiety Disorders in the DSM-5: Changes, Controversies, and Future Directions. Advances in experimental medicine and biology, 2020; 1191:187-196. Disponível em : https://pubmed.ncbi.nlm.nih.gov/32002930/
5. Yeung KS, Hernandez M, Mao JJ, Haviland I, Gubili J. Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance. Phytotherapy Research, 2018; 32(5):865-891. Disponível em : https://pubmed.ncbi.nlm.nih.gov/29464801/
6. Goyatá SLT, Avelino CCV, Santos SVM, Souza Jr DI, Gurgel MDSL, Terra FS. Effects from acupuncture in treating anxiety: integrative review. Revista Brasileira de Enfermagem, 2016; 69(3):564-71. Disponível em : https://www.scielo.br/j/reben/a/nFTpYKy5K4GY9JRXZ7FvcRc/?lang=en&format=pdf
7. Karadag E, Samancioglu S, Ozden D, Bakir E. Effects of aromatherapy on sleep quality and anxiety of patients. Nursing Critical Care, 2017; 22(2):105-112. Disponível em : https://pubmed.ncbi.nlm.nih.gov/26211735/
8. Ahmed HM. Ethnopharmacobotanical study on the medicinal plants used by herbalists in Sulaymaniyah Province, Kurdistan, Iraq. Journal of ethnobiology and ethnomedicine, 2016; 12:8. Disponível em : https://ethnobiomed.biomedcentral.com/articles/10.1186/s13002-016-0081-3
9. Brasil AX, Barbosa MO, Lemos ICS, Lima CINF, Delmondes GA, Lacerda GM, et al. Preference analysis between the use of drugs and plants in pain management in a quilombola community of the state of Ceará, Brazil. Journal of Medicinal Plants Research, 2017; 11(48): 770-777. Disponível em : https://academicjournals.org/journal/JMPR/article-full-text/6903A6867051
10. Mata R, Figueroa M, Navarrete A, Rivero-Cruz I. Chemistry and Biology of Selected Mexican Medicinal Plants. Progress in the Chemistry of Organic Natural Products, 2019; 108:1-142. Disponível em : https://pubmed.ncbi.nlm.nih.gov/30924013/
11. Hopia H, Latvala E, Liimatainen L. Reviewing The Methodology Of An Integrative Review. Scandinavian Journal Of Caring Sciences, 2016; 30(4):662-669. Disponível em : https://pubmed.ncbi.nlm.nih.gov/30924013/
12. Antonio RL, Kozasa EH, Galduróz JCF, Dorjee Y, Kalsang T, Norbu T, et al. Formulas Used by Tibetan Doctors at Men‐Tsee‐Khang in India for the Treatment of Neuropsychiatric Disorders and Their Correlation with Pharmacological Data. Phytotherapy Research, 2013; 27(4):552-563. Disponível em : https://pubmed.ncbi.nlm.nih.gov/22674653/
13. Peeke PM, Frishett S. The role of complementary and alternative therapies in women's mental health. Primary Care, 2002; 29(1):183-197. Disponível em : https://pubmed.ncbi.nlm.nih.gov/11856666/
14. Kumar V, Jaiswal AK, Singh PN, Bhattacharya SK. Anxiolytic activity of Indian Hypericum perforatum Linn: an experimental study. Indian journal of experimental biology, 2000; 38(1):36-41. Disponível em : https://pubmed.ncbi.nlm.nih.gov/11233082/
15. Van Wyk BE, Albrecht C. A review of the taxonomy, ethnobotany, chemistry and pharmacology of Sutherlandia frutescens (Fabaceae). Journal of ethnopharmacology, 2008; 119(3):620-629. Disponível em : https://pubmed.ncbi.nlm.nih.gov/18761068/
16. Smith C, Van Vuuren MJ. Central and peripheral effects of Sutherlandia frutescens on the response to acute psychological stress. Experimental biology and medicine, 2014; 239(1):123-128.
Disponível em : https://journals.sagepub.com/doi/abs/10.1177/1535370213510253?journalCode=ebmb
17. Stafford GI, Jäger AK, Van Staden J. Activity of traditional South African sedative and potentially CNS-acting plants in the GABA-benzodiazepine receptor assay. Journal of ethnopharmacology,2005;100(1):210-215. Disponível em : https://pubmed.ncbi.nlm.nih.gov/16054530/
18. García GP, López MF, Rubio G, Martín AB, Alamo C. Phytotherapy and psychiatry: Bibliometric study of the scientific literature from the last 20 years. Phytomedicine 2008; 15(8):566-576.doi:10.1016/j.phymed.2008.04.014. Disponível em: https://pubmed.ncbi.nlm.nih.gov/18583120/
19. Sarris J, La PE, Schweitzer I. Kava: a comprehensive review of efficacy, safety, and psychopharmacology. Australian and New Zealand Journal of Psychiatry, 2011; 45(1):27-35. Disponível em : https://pubmed.ncbi.nlm.nih.gov/21073405/
20. Xie W, Zhang X, Wang T, Hu J. Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L. (Luobuma): A review. J. ethnopharmacol. 2012 [citado 2017 Out 21];141(1):1-8. Disponível em : https://pubmed.ncbi.nlm.nih.gov/22421379/
21. Sahib NG, Anwar F, Gilani AH, Hamid AA, Saari N, Alkharfy KM. Coriander (Coriandrum sativum L.): A Potential Source of High-Value Components for Functional Foods and Nutraceuticals- A Review. Phytotherapy Research, 2013; 27(10):1439-1456. Disponível em : https://pubmed.ncbi.nlm.nih.gov/23281145/
22. Miroddi M, Calapai G, Navarra M, Minciullo PL, Gangemi S. Passiflora incarnata L.: Ethnopharmacology, clinical application, safety and evaluation of clinical trials. Journal of ethnopharmacology, 2013; 150(3):791-804. Disponível em : https://pubmed.ncbi.nlm.nih.gov/24140586/
23. Nair JJ, Staden J. Traditional usage, phytochemistry and pharmacology of the South African medicinal plant Boophone disticha (L.f.) Herb.(Amaryllidaceae). Journal of ethnopharmacology, 2014; 151(1):12-26. Disponível em : https://pubmed.ncbi.nlm.nih.gov/24211396/
24. Pote W, Musarira S, Chuma, D, Gadaga LL, Mwandiringana E, Tagwireyi D. Effects of a hydroethanolic extract of Boophone disticha bulb on anxiety-related behaviour in naive BALB/c mice. Journal of ethnopharmacology, 2018; 214:218-224. Disponível em : https://pubmed.ncbi.nlm.nih.gov/29223391/
25. Shakeri A, Sahebkar A, Javadi B. Melissa officinalis L. A review of its traditional uses, phytochemistry and pharmacology. Journal of ethnopharmacology, 2016; 188:204-228. Disponível em : https://pubmed.ncbi.nlm.nih.gov/27167460/
26. Luz DA, Pinheiro AM, Silva ML, Monteiro MC, Prediger RD, Ferraz Maia CS, et al. Ethnobotany, phytochemistry and neuropharmacological effects of Petiveria alliacea L. (Phytolaccaceae): A review. Journal of ethnopharmacology, 2014; 153(1):641-649. Disponível em : https://pubmed.ncbi.nlm.nih.gov/26944236/
27. Blainski A, Piccolo VK, Mello JC, de Oliveira RM. Dual effects of crude extracts obtained from Petiveria alliacea L. (Phytolaccaceae) on experimental anxiety in mice. Journal of ethnopharmacology, 2010; 128(2):541-4. Disponível em : https://pubmed.ncbi.nlm.nih.gov/20079419/
28. Nikfarjam M, Bahmani M, Soureshjani SH. Phytotherapy for anxiety in Iran: A review of the most important. Anti-anxiety medicinal plants. Journal of Chemical and Pharmaceutical Sciences, 2016; 9(3):1235-1241. Disponível em : https://www.researchgate.net/publication/309078491_Phytotherapy_for_anxiety_in_Iran_A_review_of_the_most_important_Anti-Anxiety_medicinal_plants
29. Alizadeh A, Aghaee Z. Essential oil constituents, phenolic content and antioxidant activity of Lavandula stricta Delile growing wild in southern Iran. Natural Products Research, 2016; 30(19):2253-7. Disponível em : https://pubmed.ncbi.nlm.nih.gov/26959122/
30. Aydin E, Hritcu L, Dogan G, Hayta S, Bagci E. The effects of inhaled Pimpinella peregrina essential oil on scopolamine-induced memory impairment, anxiety, and depression in laboratory rats. Molecular Neurobiology, 2016; 53(9):6557-6567. Disponível em : https://pubmed.ncbi.nlm.nih.gov/26768430/
31. Assad T, Khan RA. Effect of methanol extract of Trigonella foenum-graecum L. seeds on anxiety, sedation and motor coordination. Metabolic Brain Disease, 2017; 32(2):343-349. Disponível : https://pubmed.ncbi.nlm.nih.gov/27639708/
32. Sarris J, Mcintyre E, Camfield DA. Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. CNS Drugs, 2013; 27(4):301-19. Disponível em : https://pubmed.ncbi.nlm.nih.gov/23653088/
33. Vafaei AA, Miladi-Gorgi H, Moghimi HR, Ameri M. The effect of fruit Cassia fistula aqueous extract on sleeping time and the level of anxiety in mice. Journal of Gorgan University of Medical Sciences, 2011; 12(4):1-6. Disponível em : https://goums.ac.ir/journal/article-1-851-en.html
34. Boskabady MH, Shafei MN, Saberi Z, Amini S. Pharmacological effects of Rosa damascena. Iranian Journal of Basic Medicinal Science, 2011; 14(4):295–307. Disponível em : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586833/
35. Rubalcava CL, Camarena EE. Mexican medicinal plants with anxiolytic or antidepressant activity: Focus on preclinical research. Journal of ethnopharmacology, 2016; 186:377-391. Disponível em : https://pubmed.ncbi.nlm.nih.gov/27021688/
Published
2024-04-16
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