Benzodiazepínicos: farmacologia, uso, contaminação ambiental e métodos analíticos para sua determinação

  • Ulana Chaves Sarmento HUMAP - EBSERH
  • Tatiana Pires de Souza HUMAP-UFMS-EBSERH
  • Aline Tiveron Marini
  • Elaine Cristina Melhado Bidoia Lopes

Resumo

Os benzodiazepínicos (BZD) , desde que foram descobertos, estão entre os fármacos mais prescritos para tratar ansiedade, insônia, dependência química, agitação, síndrome do pânico e convulsão, além de promoverem efeitos sedativos e relaxantes musculares. Eles também são estudados como potenciais contaminantes ambientais, pois o elevado consumo nas medicinas humana e veterinária e o descarte inadequado acarretam em uma deposição significativa desses fármacos e seus metabólitos no meio ambiente.Diante da importância sobre essa classe de fármacos, realizou –se uma busca direta em bases de dados indexadas com o objetivo de nortear futuros trabalhos na área de controle de qualidade e monitoramento ambiental de BZD, avaliação de efeitos tóxicos dos fármacos e dos respectivos produtos de degradação em organismos aquáticos além de fazer uma revisão bibliográfica acerca de seu uso, origem, relação estrutura atividade, consumo e os métodos analíticos para sua determinação.

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Publicado
2022-12-07
Como Citar
CHAVES SARMENTO, U.; PIRES DE SOUZA, T.; TIVERON MARINI, A.; MELHADO BIDOIA LOPES, E. C. Benzodiazepínicos: farmacologia, uso, contaminação ambiental e métodos analíticos para sua determinação. Perspectivas Experimentais e Clínicas, Inovações Biomédicas e Educação em Saúde (PECIBES), v. 8, n. 2, p. 15-24, 7 dez. 2022.
Seção
Artigos de Revisão