Lesão renal aguda em pacientes adultos expostos a covid-19: revisão sistemática
Resumo
Por se tratar de uma infecção respiratória, o SARS-CoV-2 se dissemina por contato direto com o infectado. Quando em estado grave, infectados podem apresentar sintomas de insuficiência respiratória, cardiovascular, renal e outros órgãos devido a resposta inflamatória exacerbada. Existem casos que se complicam levando os indivíduos à unidade de terapia intensiva e até mesmo ao óbito. O objetivo deste estudo foi avaliar o desenvolvimento de Lesão Renal Aguda em adultos expostos a COVID 19. A metodologia foi a revisão sistemática. Os estudos incluídos detectaram diferentes fatores preditores para o desenvolvimento da LRA, entre eles, Hipertensão Arterial Sistêmica, Diabetes mellitus e obesidade; as LRAs foram classificadas de acordo com o KDIGO e o Estágio I representou a maioria dos casos, porém o Estágio III apresentou a maior mortalidade; o uso de terapias, drogas e tratamentos de alto custo dificultam a condução do paciente, tornando-o um desafio para os sistemas de saúde.
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ÖZTÜRK Savas et al. Impact of hospital-acquired acute kidney injury on Covid-19 outcomes
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PECLY, Inah Maria D. et al. A review of Covid-19 and acute kidney injury: from
pathophysiology to clinical results. Brazilian Journal of Nephrology, São Paulo, v. 43, n. 4,
p. 551-571, maio 2021. Disponível em: https://www.bjnephrology.org/article/uma-revisao-da-
covid-19-e-lesao-renal-aguda-da-fisiopatologia-aosresultados-clinicos/. Acesso em: 21 out.
2022.
PENG Suyuan et al. Early versus late acute kidney injury among patients with COVID-19-a
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2102, 4 dez. 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33275762/. Acesso em:
21 out. 2022.
PEREIRA, Mauricio Gomes; Galvão, Thaís Freire. Extração, avaliação da qualidade e síntese
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http://scielo.iec.gov.br/scielo.php?script=sci_arttext&pid=S1679-
49742014000300021&lng=pt&nrm=iso. Acesso em 14 out. 2022.
PIÑEIRO Gaston J. et al. Severe acute kidney injury in critically ill COVID-19 patients.
Journal of Nephrology., v. 34. n. 2, p. 285-293, abr. 2021. Disponível em:
https://pubmed.ncbi.nlm.nih.gov/33387345/. Acesso em: 19 out. 2022.
POST Adrian et al. Kidney Infarction in Patients With COVID-19. American Journal of
Kidney Diseases, v. 76, n. 3, p. 431-435, doi: 10.1053/j.ajkd.2020.05.004. Epub 2020 may
29, 20 sep. 2020,. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32479921/. Acesso em: 19
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SAMAAN Farid et al. COVID-19-associated acute kidney injury patients treated with renal
replacement therapy in the intensive care unit: A multicenter study in São Paulo, Brazil. PLoS
One, San Francisco, v. 17, n. 1, e0261958, 14 jan. 2022. Disponível em:
https://pubmed.ncbi.nlm.nih.gov/35030179/. Acesso em: 21 out. 2022.
SEE Yong et al. Risk Factors for Development of Acute Kidney Injury in COVID-19
Patients: A Retrospective Observational Cohort Study. Nephron., v. 145, n. 3, p. 256-264,
2021. doi: 10.1159/000514064. Epub 2021 Mar 29. Disponível em:
https://pubmed.ncbi.nlm.nih.gov/33780937/. Acesso em: 21. out. 2022.
SILVA, Júlia Maria Moreira et al. Manejo da lesão renal aguda: uma revisão narrativa.
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https://acervomais.com.br/index.php/saude/article/view/7072. Acesso em: 21. out.2022.
SILVA Natália; RIBEIRO, Catarina Isabel. COVID-19 and acute kidney injury – A new
medical condition. Portuguese Journal of Nephrology Hypertension, v. 34, n. 4, p. 193-
196, 15 dez. 2020. Disponível em:
https://www.researchgate.net/publication/348414238_COVID-19_and_acute_kidney_injury_-
_A_new_medical_condition. Acesso em: 21. out. 2022.
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546258/. Acesso em: 21. out. 2022.
WANG Feilong et al. Epidemiology and Outcomes of Acute Kidney Injury in COVID-19
Patients with Acute Respiratory Distress Syndrome: A Multicenter Retrospective Study.
Blood Purif. v. 50, n. 4-5, p. 499-505, jul. 2021. Disponível em:
https://pubmed.ncbi.nlm.nih.gov/33291098/. Acesso em: 21. out. 2022.
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Acesso em: 19. out. 2022.
YILDIRIM Cigdem et al. Early predictors of acute kidney injury in COVID-19 patients.
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https://www.karger.com/Article/FullText/522100#. Acesso 19. Out. 2022.
for the Management of Blood Pressure in Chronic Kidney Disease. Kidney International,
Utah, v. 99, n. 3, p. 559-569, mar. 2021. DOI: 10.1016/j.kint.2020.10.026. PMID:
33637203. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33637203/. Acesso em: 19. out.
2022.
DIEBOLD, Matthias et al. Acute kidney injury in patients with COVID-19: a retrospective
cohort study from Switzerland. Swiss Med Wkly, Switzerland, v. 151, n. 910, 1 mar. 2021.
DOI: 10.4414/smw.2021.20482. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33706383/.
Acesso em: 19. out. 2022.
GATES, Bill. Responding to Covid-19: a once-in-a-century pandemic? The New England
Journal of Medicine, Massachusetts, v. 382, n. 18, p. 1677-1679, 30 abr. 2020. Disponível
em: https://www.nejm.org/doi/full/10.1056/nejmp2003762. Acesso em: 19. out. 2022.
GUAN, W. et al. Clinical characteristics of coronavirus disease 2019 in China. The New
England Journal of Medicine, Massachusetts, v. 382, n. 18, p. 1708-1720, 30 abr. de 2020.
Disponível em: https://www.nejm.org/doi/full/10.1056/nejmoa2002032. Acesso em: 19. out.
2022.
HUSAIN-SYED, F. et al. Acute kidney injury and urinary biomarkers in hospitalized patients
with coronavirus disease-2019. Nephrology Dialysis Transplantation, Giessen, v. 35, n. 7,
p. 1271-1274, 1 jul. 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32691068/.
Acesso em: 19. out. 2022.
ISER, Betine Pinto Moehlecke et al. Definição de caso suspeito da COVID-19: uma revisão
narrativa dos sinais e sintomas mais frequentes entre os casos confirmados. Epidemiol. Serv.
Saúde, Brasília, v. 29, n. 3, [citado 2022-10-19], e2020233, 2020. Disponível em:
http://scielo.iec.gov.br/scielo.php?script=sci_arttext&pid=S1679-
49742020000300035lng=pt&nrm=iso. Acesso em: 19. out. 2022.
JIN, Ying-Hui et al. A rapid advice guideline for the diagnosis and treatment of 2019 novel
coronavirus (2019-nCoV) infected pneumonia (standard version). Mil. Med. Research, v. 7.
n. 1, p. 1-23, 6 fev. 2020. Disponível em: https://doi.org/10.1186/s40779-020-0233-6. Acesso
em: 19. out. 2022.
KIDNEY DISEASE: IMPROVING GLOBAL OUTCOMES (KDIGO). Acute Kidney Injury
Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int
Suppl. 2012;2(Suppl 1):1-138.
LI, Ruiyun et al. Substantial undocumented infection facilitates the rapid dissemination of
novel coronavirus (SARS-CoV2). Science, v. 368. n. 6490, p. 489-493, 1 maio 2020.
Disponível em: https://pubmed.ncbi.nlm.nih.gov/32029004/. Acesso em: 06 out. 2022.
MOHER, David et al. Preferred reporting items for systematic reviews and meta‐analyses:
The PRISMA statement. PLoS Medicine, San Francisco, v. 6, n. 7, e1000097–e1000097, 21
jul. 2009. . Disponível em:
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1000097 . Acesso em:
06 out. 2022.
MONTEIRO Wuelton M. et al. Driving forces for Covid-19 clinical trials using chloroquine:
the need to choose the right research questions and outcomes. Rev. Soc. Bras. Med. Trop.,
Uberaba, n. 53, p. 1-3, 6 abr. 2020. Disponível em:
https://www.scielo.br/j/rsbmt/a/68vywsQ6ShmGjQb3RcrmvyP/?lang=en. Acesso em: 19.
out. 2022.
MORSE Jared S. et al. Learning from the past: possible urgent prevention and treatment
options for severe acute respiratory infections caused by 2019-nCoV. Chembiochem,
Weinheim, v. 21, n. 5, p. 730-738, 2 mar. 2020. Disponível em:
https://pubmed.ncbi.nlm.nih.gov/32022370/. Acesso em: 19. out. 2022.
NASER Maryam N. et al. Risk factors, predictions, and progression of acute kidney injury in
hospitalized COVID-19 patients: An observational retrospective cohort study. PLoS One,
San Francisco, v. 16, n. 9, e0257253, 29 set. 2021. Disponível em:
https://pubmed.ncbi.nlm.nih.gov/34587189/. Acesso em: 21 out. 2022.
NASIRI Naser et al. A. Kidney Complications of COVID-19: A Systematic Review and
Meta-Analysis. Journal of Research in Health Sciences, Hamadan, v. 21, n. 1, e00503. doi:
10.34172/jrhs.2021.39, PMID: 34024761, PMCID: PMC8957695, 12 jan. 2021. Disponível
em https://pubmed.ncbi.nlm.nih.gov/34024761/. Acesso em: 19 out. 2022.
OUZZANI, Mourad et al. Rayyan: um aplicativo web e móvel para revisões sistemáticas.
Systematic Reviews, v. 5, n. 210, 5 dez. 2016. Disponível em:
https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-016-0384-4.
Acesso em: 06 out. 2022.
ÖZTÜRK Savas et al. Impact of hospital-acquired acute kidney injury on Covid-19 outcomes
in patients with and without chronic kidney disease: a multicenter retrospective cohort study.
Turkish Journal of Medical Sciences, Ancara, v. 51, n. 3, p. 947-961, 28 jun. 2021.
Disponível em: https://pubmed.ncbi.nlm.nih.gov/33611868/. Acesso em: 06 out. 2022.
PECLY, Inah Maria D. et al. A review of Covid-19 and acute kidney injury: from
pathophysiology to clinical results. Brazilian Journal of Nephrology, São Paulo, v. 43, n. 4,
p. 551-571, maio 2021. Disponível em: https://www.bjnephrology.org/article/uma-revisao-da-
covid-19-e-lesao-renal-aguda-da-fisiopatologia-aosresultados-clinicos/. Acesso em: 21 out.
2022.
PENG Suyuan et al. Early versus late acute kidney injury among patients with COVID-19-a
multicenter study from Wuhan, China. Nephrol. Dial. Transplant., v. 35, n. 12, p. 2095-
2102, 4 dez. 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33275762/. Acesso em:
21 out. 2022.
PEREIRA, Mauricio Gomes; Galvão, Thaís Freire. Extração, avaliação da qualidade e síntese
dos dados para revisão sistemática. Epidemiol. Serv. Saúde [online], Brasília, v. 23, n.3
[citado 2022-10-17], p. 577-578, set. 2014. Disponível em:
http://scielo.iec.gov.br/scielo.php?script=sci_arttext&pid=S1679-
49742014000300021&lng=pt&nrm=iso. Acesso em 14 out. 2022.
PIÑEIRO Gaston J. et al. Severe acute kidney injury in critically ill COVID-19 patients.
Journal of Nephrology., v. 34. n. 2, p. 285-293, abr. 2021. Disponível em:
https://pubmed.ncbi.nlm.nih.gov/33387345/. Acesso em: 19 out. 2022.
POST Adrian et al. Kidney Infarction in Patients With COVID-19. American Journal of
Kidney Diseases, v. 76, n. 3, p. 431-435, doi: 10.1053/j.ajkd.2020.05.004. Epub 2020 may
29, 20 sep. 2020,. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32479921/. Acesso em: 19
out. 2022.
RUSSO Elisa et al. Kidney disease and all-cause mortality in patients with COVID-19:
hospitalized in Genoa, Northern Italy. Journal of Nephrology, v. 34, n. 1, p. 173-183, fev.
2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33025516/. Acesso 21 out. 2022.
SAMAAN Farid et al. COVID-19-associated acute kidney injury patients treated with renal
replacement therapy in the intensive care unit: A multicenter study in São Paulo, Brazil. PLoS
One, San Francisco, v. 17, n. 1, e0261958, 14 jan. 2022. Disponível em:
https://pubmed.ncbi.nlm.nih.gov/35030179/. Acesso em: 21 out. 2022.
SEE Yong et al. Risk Factors for Development of Acute Kidney Injury in COVID-19
Patients: A Retrospective Observational Cohort Study. Nephron., v. 145, n. 3, p. 256-264,
2021. doi: 10.1159/000514064. Epub 2021 Mar 29. Disponível em:
https://pubmed.ncbi.nlm.nih.gov/33780937/. Acesso em: 21. out. 2022.
SILVA, Júlia Maria Moreira et al. Manejo da lesão renal aguda: uma revisão narrativa.
Revista Eletrônica Acervo Saúde, v. 13, n. 5, 26 maio 2021. Disponível em:
https://acervomais.com.br/index.php/saude/article/view/7072. Acesso em: 21. out.2022.
SILVA Natália; RIBEIRO, Catarina Isabel. COVID-19 and acute kidney injury – A new
medical condition. Portuguese Journal of Nephrology Hypertension, v. 34, n. 4, p. 193-
196, 15 dez. 2020. Disponível em:
https://www.researchgate.net/publication/348414238_COVID-19_and_acute_kidney_injury_-
_A_new_medical_condition. Acesso em: 21. out. 2022.
TARRAGÓN Blanca et al. J. Acute kidney failure in patients admitted due to COVID-19.
Nefrologia (Engl Ed), v. 41, n. 1, p. 34-40, jan./fev. 2021, English, Spanish. Disponível em:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546258/. Acesso em: 21. out. 2022.
WANG Feilong et al. Epidemiology and Outcomes of Acute Kidney Injury in COVID-19
Patients with Acute Respiratory Distress Syndrome: A Multicenter Retrospective Study.
Blood Purif. v. 50, n. 4-5, p. 499-505, jul. 2021. Disponível em:
https://pubmed.ncbi.nlm.nih.gov/33291098/. Acesso em: 21. out. 2022.
WORLD HEALTH ORGANIZATION. Novel coronavirus (2019-nCoV) situation report 1.
WHO, Geneva, 21 jan. 2020. . Disponível em: https://www.who.int/docs/default-
source/coronaviruse/situation-reports/20200121-sitrep-1-2019-ncov.pdf?sfvrsn=20a99c10_4.
Acesso em: 19. out. 2022.
YILDIRIM Cigdem et al. Early predictors of acute kidney injury in COVID-19 patients.
Nephrology (Carlton), v. 26, n. 6, p. 513-521, doi: 10.1111/nep.13856. Epub 2021 Feb 9,
jun. 2021. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014704/. Acesso
em: 19. Out. 2022.
ZU, Zi Yue et al. Coronavírus disease 2019 (Covid-19): a perspective from China.
Radiology. v. 296, n. 2, ago. 2020. Disponível em:
https://pubmed.ncbi.nlm.nih.gov/32083985/. Acesso em: 19. Out. 2022
ZOLOTOV, Eli et al. Can Renal Parameters Predict the Mortality of Hospitalized COVID-19
Patients?. Kidney Blood Press Res.. v. 47, n. 5, p. 309–319, 20 jan. 2022. Disponível em:
https://www.karger.com/Article/FullText/522100#. Acesso 19. Out. 2022.
Publicado
2023-07-21
Como Citar
DA COSTA MELO, L. Lesão renal aguda em pacientes adultos expostos a covid-19: revisão sistemática. Perspectivas Experimentais e Clínicas, Inovações Biomédicas e Educação em Saúde (PECIBES), v. 9, n. 1, p. 47-55, 21 jul. 2023.
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