Orbital - Vol. 13 No. 4 - July-September 2021
REVIEWS

Effect of Methods and Catalysts on the One-pot Synthesis of Tetrahydropyridine Derivatives: A Mini-Review

Ajay Thakur
Chandigarh University, Mohali, Punjab-140413
Ruchi Bharti
Chandigarh University, Mohali, Punjab-140413
Renu Sharma
Department of Chemistry, University Institute of Sciences, Chandigarh University, NH-95 Chandigarh-Ludhiana Highway, Mohali, Punjab
Graphical abstract
Published October 5, 2021
Keywords
  • Bioactivity; Catalysis; heterocyclic compounds; Multi-component Reactions; Organic Synthesis; Tetrahydropyridine Derivatives
How to Cite
(1)
Thakur, A.; Bharti, R.; Sharma, R. Effect of Methods and Catalysts on the One-Pot Synthesis of Tetrahydropyridine Derivatives: A Mini-Review. Orbital: Electron. J. Chem. 2021, 13, 335-349.

Abstract

As heterocyclic nitrogen molecules, tetrahydropyridines have been recognized as significant constituents of many natural and synthetic compounds, many of which have interesting biological and pharmacological properties. Tetrahydropyridines (THPs) play a pivotal role in synthesizing a range of remedial compounds. They have exhibited impressive curative efficacy for the treatment of numerous diseases. Due to this reason, they are attractive synthetic targets for organic chemists. Several techniques and schemes have been adopted for the synthesis of these molecules. Among these, multicomponent reactions (MCRs) are proved to be one of the best tools for achieving compounds containing complex diversity in a single step and production of their vast libraries. Along with this, the employment of various catalysts makes this technique more vibrant. This review article discussed different catalysts adopted in the synthesis of tetrahydropyridine derivatives via multicomponent reactions to provide information for the development of new-fangled processes aiming at less reaction time, better yield, and minimum side effects.

DOI: http://dx.doi.org/10.17807/orbital.v13i4.1585