Synthesis, Controlled Release and Kinetic Studies of Polyacrylic Acid-polyethylene Oxide/β-cyclodextrin Nano-interpolymer Complex with Naproxen
- nano-interpolymer complex,
- naproxen delivery,
- β-cyclodextrin,
- polyacrylic acid,
- polyethylene oxide
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Abstract
The aim of this work is synthesis of a nano-interpolymer complex based on polyacrylic acid-polyethylene oxide (PAA-PEO) and β-cyclodextrin as a nanocarrier biodegradable drug delivery system. Host-guest method was used to make the nano-interpolymer complex in which beta cyclodextrin (β-CD) was applied as a suitable host. The nano-interpolymer complex was characterized by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Hydrogen bonding formation between two polymers was proved by infrared spectroscopy method. The particle size in range of 12 nanometer was estimated by TEM. In the next step Naproxen (Nap) was loaded on the PAA-PEO/β-CD three component nano-interpolymer complex Then, release of Naproxen was investigated at 37 oC (human body temperature) and pH of 2.1 (gastric pH) and 7.4 (intestine pH) with UV spectrophotometer. Optimization of the PAA/PEO/β CD were investigated and by changing the amount of β-CD. Kinetic studies were also performed by using different kinetic models to investigate the Naproxen release rate.