Orbital - Vol. 12 No. 1 - January-March 2020
SHORT COMMUNICATIONS

Optimization of Conditions for the Synthesis and Oxidation of 5,8-Dimethoxy-2-methyl-3,4-dihydroisoquinolin-1(2H)-one into Novel 2-Methylisoquinoline-1,5,8(2H)-trione

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  • Basharat Ali,
  • Faiz Ahmed,
  • Nusrat Shafiq,
  • Muhammad Nasrula
Basharat Ali
Department of Chemistry; Khwaja Fareed University of Engineering & Information Technology, Rahim Yar Khan-64200, Punjab
Faiz Ahmed
Department of Chemistry, Government College University Faisalabad
Nusrat Shafiq
Department of Chemistry, Government College Women University Faisalabad, Faisalabad-38000, Punjab
Muhammad Nasrula
Department of Chemistry, University Block Punjab College, Chishtian-62350, Punjab
Published May 2, 2020
Keywords
  • catalyst ratio,
  • ceric ammonium nitrate,
  • isoquinolones,
  • N-methylation,
  • oxidation
How to Cite
(1)
Ali, B.; Ahmed, F.; Shafiq, N.; Nasrula, M. Optimization of Conditions for the Synthesis and Oxidation of 5,8-Dimethoxy-2-Methyl-3,4-Dihydroisoquinolin-1(2H)-One into Novel 2-Methylisoquinoline-1,5,8(2H)-Trione. Orbital: Electron. J. Chem. 2020, 12, 30-33.

Copyright (c) 2020 Orbital: The Electronic Journal of Chemistry

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Abstract

Due to stability issue of isoquinolone’s their N-methylation is a challenging task, achieved the synthesis of N-methylated 2-methylisoquinoline-1,5,8(2H)-trione using readily available precursor 2-(2,5-dimethoxyphenyl)ethanamine via multistep strategy, finally oxidation of 5,8-dimethoxy-2-methyl-3,4-dihydroisoquinolin-1(2H)-one with ceric ammonium nitrate (CAN) lead to target isoquinolone in good yield, further oxidation conditions in final step were optimized using different catalyst ratio, reaction time and temperature conditions.

DOI: http://dx.doi.org/10.17807/orbital.v12i1.143

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