Synthesis, DFT Calculation and Biological Activity of Some Organotellurium Compounds Containing Azomethine Group

Abstract

The reaction of (4-amino-2,3-dichlorophenyl)mercury (II) chloride with 3,4-dihydroxy benzaldehyde produce the organomercury compound 1 in 82% yield. Tellurated of 1 with tellurium (IV) tetrabromide gave the tellurium (IV) tribromide Schiff base compound 2. The reaction between 1 and 2 gave the diaryltelluride dibromide compound 4. Reduction of 2 and 4 by hydrazine hydrate gave diaryal ditelluride 3 and diaryal telluride 5 respectively in 53% and 61% yields. All new compounds were characterized by FT-IR, NMR and mass spectroscopy. The geometry optimization of molecular structure and energies was calculated using density functional theory by Material studio-DMol3 program. The synthesized compounds were screened for their antibacterial activity against Escherichia coli, Pseudomonas spp., Klebsiella pneumonia, Proteus and Staphylococcus aureus. Additionally, the compounds were tested as antioxidant activity by DPPH(1,1-Diphenyl-2-picryl-hydrazyl) assay method. The compounds exhibited its have antibacterial and antioxidant activity, and the compounds 2 and 4 gave higher activity than other compounds.

DOI: http://dx.doi.org/10.17807/orbital.v11i7.1211