Orbital - Vol. 11 No. 3 - April-June 2019
FULL PAPERS

Thermodynamic Study of Comfarol Binding to Urease

PDF
  • Leila Zolghadr,
  • Gholamreza Rezaei Behbehani,
  • Adeleh Divsalar,
  • Zahra Moubarakabadi
Leila Zolghadr
Department of Chemistry, Imam Khomeini International University, Qazvin, Iran
Gholamreza Rezaei Behbehani
Department of Chemistry, Imam Khomeini International University, Qazvin, Iran
Adeleh Divsalar
Department of Cell and Molecular Sciences, Kharazmi university, Tehran, Iran
Zahra Moubarakabadi
Department of Chemistry, Imam Khomeini International University, Qazvin, Iran
Published July 6, 2019
Keywords
  • comfarol,
  • urease,
  • the extended solvation model
How to Cite
(1)
Zolghadr, L.; Behbehani, G. R.; Divsalar, A.; Moubarakabadi, Z. Thermodynamic Study of Comfarol Binding to Urease. Orbital: Electron. J. Chem. 2019, 11, 151-154.

Copyright (c) 2019 Orbital: The Electronic Journal of Chemistry

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Abstract

Isothermal Titration Calorimetry, ITC, was used to study of Jack Bean urease, JBU, binding with comfarol in phosphate buffer at pH 7.4. Data analyzing of comfarol interaction with JBU was performed by the extended solvation model and the positive cooperativity of comfarol with JBU indicates that comfarol causes stabilization of the JBU structure.

DOI: http://dx.doi.org/10.17807/orbital.v11i3.1369

PDF