Orbital - Vol. 10 No. 2 - January-March 2018

KI-Mediated Three-component Reaction of Hydroxylamine Hydrochloride with Aryl/Heteroaryl Aldehydes and Two β-Oxoesters

Asiyeh Mosallanezhad
Damghan University
Hamzeh Kiyani
Damghan University
Published April 1, 2018
  • β-dicarbonyl,
  • green,
  • isoxazole-5(4H)-ones,
  • potassium iodide,
  • water
How to Cite
Mosallanezhad, A.; Kiyani, H. KI-Mediated Three-Component Reaction of Hydroxylamine Hydrochloride With Aryl/Heteroaryl Aldehydes and Two β-Oxoesters. Orbital: Electron. J. Chem. 2018, 10, 133-139.


A KI-mediated multi-component cyclocondensation of hydroxylamine hydrochloride, aromatic/hetero-aromatic aldehydes, and   ethyl acetoacetate or 4-chloroethyl acetoacetate to form isoxazole-5(4H)-one heterocycles is described. The reaction employs readily accessible starting reactants and provides a range of synthetically isoxazole-5(4H)-ones in good to high yields. Reactions were performed in water as a green medium at room temperature (RT) without heating, microwave irradiation or sonication.  Reusability of the reaction medium is also a noteworthy characteristic of this reaction.

DOI: http://dx.doi.org/10.17807/orbital.v10i2.1134