KI-Mediated Three-component Reaction of Hydroxylamine Hydrochloride with Aryl/Heteroaryl Aldehydes and Two β-Oxoesters
Hamzeh Kiyani
- β-dicarbonyl,
- green,
- isoxazole-5(4H)-ones,
- potassium iodide,
- water
Copyright (c) 2018 Orbital: The Electronic Journal of Chemistry
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Abstract
A KI-mediated multi-component cyclocondensation of hydroxylamine hydrochloride, aromatic/hetero-aromatic aldehydes, and ethyl acetoacetate or 4-chloroethyl acetoacetate to form isoxazole-5(4H)-one heterocycles is described. The reaction employs readily accessible starting reactants and provides a range of synthetically isoxazole-5(4H)-ones in good to high yields. Reactions were performed in water as a green medium at room temperature (RT) without heating, microwave irradiation or sonication. Reusability of the reaction medium is also a noteworthy characteristic of this reaction.