KI-Mediated Three-component Reaction of Hydroxylamine Hydrochloride with Aryl/Heteroaryl Aldehydes and Two β-Oxoesters
- potassium iodide,
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A KI-mediated multi-component cyclocondensation of hydroxylamine hydrochloride, aromatic/hetero-aromatic aldehydes, and ethyl acetoacetate or 4-chloroethyl acetoacetate to form isoxazole-5(4H)-one heterocycles is described. The reaction employs readily accessible starting reactants and provides a range of synthetically isoxazole-5(4H)-ones in good to high yields. Reactions were performed in water as a green medium at room temperature (RT) without heating, microwave irradiation or sonication. Reusability of the reaction medium is also a noteworthy characteristic of this reaction.