Orbital - Vol. 9 No. 4 - July - September 2017

Synthetic and Biological Studies of Ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives

Kandarp H. Patel
Government Science College, Gandhinagar
Yogesh S. Patel
Department of Research and Development, Adventus Laboratories (India) Pvt. Ltd. 495/7–8, GIDC, Makarpura, Vadodara-390010, Gujarat, India
Published October 2, 2017
  • antimicrobial activity,
  • solvent-free,
  • one-pot synthesis,
  • thiazolo[3,2-a]pyrimidine
How to Cite
Patel, K. H.; Patel, Y. S. Synthetic and Biological Studies of Ethyl-7-Methyl-3-(naphthalen-2-Yl)-5-Phenyl-5H-thiazolo[3,2-a]pyrimidine-6-Carboxylate Derivatives. Orbital: Electron. J. Chem. 2017, 9, 219-224.


Novel series of ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a] pyrimidine-6-carboxylate (4a–g) heterocyclic compounds have been synthesized in a one-pot reaction under solvent-free conditions from 4-(naphthalen-2-yl)thiazol-2-amine (1), various aromatic benzaldehyde (2a–g) and ethylacetoacetate (3). All the synthesized compounds were duly characterized by physic chemical analysis and various spectrometric technique viz., NMR, CMR and FT–IR spectral features. Compounds 4a–g were screened for their in vitro antibacterial activity against Gram-positive bacterial strains (Bacillus subtilis and Staphylococcus aureus) and Gram-negative bacterial strains (Salmonella typhimurium and Escherichia coli). Compounds 4a–g were also examined for antifungal activity against different fungal strains, i.e. Penicillium expansumBotryodiplodia theobromaeNigrospora sp., and Trichothesium sp.

DOI: http://dx.doi.org/10.17807/orbital.v9i4.879