Lanthanide Chlorides Decrease the Antioxidant Property of Human Serum Albumin

Abstract

Substantial conformational changes of human serum albumin, HSA, induced by Lanthanide chlorides (Ce^3+, La^3+, Er³⁺) in phosphate buffer, 10 mmol L^-1 at pH 7.4, was studied by Isothermal Titration Calorimetry, ITC. The strong negative cooperativity of Lanthanide chlorides interaction with HSA recovered from the extended solvation model, indicates that HSA denatures as a result of its interaction with toxic Lanthanide chlorides.

DOI: http://dx.doi.org/10.17807/orbital.v9i1.941