Orbital - Vol. 9 No. 1 - January - March 2017
FULL PAPERS

Lanthanide Chlorides Decrease the Antioxidant Property of Human Serum Albumin

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  • Mahmood Payeghadr,
  • Gholamreza Rezaei Behbehani,
  • Monir Shalbafan
Mahmood Payeghadr
Department of Chemistry, Payame Noor University
Gholamreza Rezaei Behbehani
G. Rezaei Behbehani, chemistry Department, IKIU, Qazvin Iran
Monir Shalbafan
Department of Chemistry, Imam Khomeini International University
Published March 31, 2017
Keywords
  • human serum albumin,
  • the extended solvation model
How to Cite
(1)
Payeghadr, M.; Behbehani, G. R.; Shalbafan, M. Lanthanide Chlorides Decrease the Antioxidant Property of Human Serum Albumin. Orbital: Electron. J. Chem. 2017, 9, 72-75.

Copyright (c) 2017 Orbital: The Electronic Journal of Chemistry

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Abstract

Substantial conformational changes of human serum albumin, HSA, induced by Lanthanide chlorides (Ce3+, La3+, Er3+) in phosphate buffer, 10 mmol L-1 at pH 7.4, was studied by Isothermal Titration Calorimetry, ITC. The strong negative cooperativity of Lanthanide chlorides interaction with HSA recovered from the extended solvation model, indicates that HSA denatures as a result of its interaction with toxic Lanthanide chlorides.

DOI: http://dx.doi.org/10.17807/orbital.v9i1.941

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