FULL PAPERS
Published
March 31, 2017
Keywords
- human serum albumin,
- the extended solvation model
How to Cite
(1)
Payeghadr, M.; Behbehani, G. R.; Shalbafan, M. Lanthanide Chlorides Decrease the Antioxidant Property of Human Serum Albumin. Orbital: Electron. J. Chem. 2017, 9, 72-75.
Copyright (c) 2017 Orbital: The Electronic Journal of Chemistry

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Abstract
Substantial conformational changes of human serum albumin, HSA, induced by Lanthanide chlorides (Ce3+, La3+, Er3+) in phosphate buffer, 10 mmol L-1 at pH 7.4, was studied by Isothermal Titration Calorimetry, ITC. The strong negative cooperativity of Lanthanide chlorides interaction with HSA recovered from the extended solvation model, indicates that HSA denatures as a result of its interaction with toxic Lanthanide chlorides.