Eco-friendly Synthesis, Spectral Correlation Analysis, and Antimicrobial Activities of Substituted (E)-1-benzylidene-2-(3-nitrophenyl)hydrazines

Abstract

In the present study, a series of ten substituted (E)-1-benzylidene-2-(3-nitrophenyl)hydrazine compounds have been synthesized by condensation of  3-nitrophenylhydrazine with various substituted benzaldehydes using SiO₂-H₃PO₄ catalyst under solvent free condition. This method involves shorter reaction time (5-10 minutes) with excellent yield (80-90%). The structures of the synthesized (E)-1-benzylidene-2-(3-nitrophenyl)hydrazines have been characterized by their physical constants, UV, FT-IR and NMR spectral data. The characterized UV, FT-IR and NMR spectral data have been correlated with Hammett constants using single-linear and multi-linear regression analysis. From the results of single-linear and multi-linear regression analysis the effect of substituents on the spectral data have been discussed.  The antimicrobial activities of all the (E)-1-benzylidene-2-(3-nitrophenyl)hydrazine compounds have been tested using Bauer-Kirby method.

DOI: http://dx.doi.org/10.17807/orbital.v8i5.865