Orbital - Vol. 15 No. 3 - July-September 2023
FULL PAPERS

The Green and Efficient One-pot Synthesis of Tetrahydrobenzo[b]pyran Derivatives

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  • Bhaskar P. Ankush,
  • Balasaheb V. Shitole,
  • Nana V. Shitole
Bhaskar P. Ankush
Swami Ramanand Teerth Marathwada University
Balasaheb V. Shitole
Swami Ramanand Teerth Marathwada University
Nana V. Shitole
Swami Ramanand Teerth Marathwada University Nanded
DOI: https://doi.org/10.17807/orbital.v15i3.17906
Published October 11, 2023
Keywords
  • Aldehydes,
  • Dimedone,
  • Glutamic acid,
  • Multicomponent reactions,
  • Tetrahydrobenzo[b]pyran
How to Cite
(1)
Ankush, B. P.; Shitole, B. V.; Shitole, N. V. The Green and Efficient One-Pot Synthesis of Tetrahydrobenzo[b]pyran Derivatives. Orbital: Electron. J. Chem. 2023, 15, 148-152.

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Abstract

Glutamic acid is used as an efficient organocatalyst for one-pot synthesis of tetrahydrobenzo [b]pyran via condensation of an aromatic aldehyde, dimedone and malononitrile in ethanol: water (1:4) as solvent at reflux temperature. The short reaction time, cleaner reaction, and easy workup make this protocol practical and economically attractive.

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