FULL PAPERS
Published 2023-10-11
Keywords
- Aldehydes,
- Dimedone,
- Glutamic acid,
- Multicomponent reactions,
- Tetrahydrobenzo[b]pyran
How to Cite
(1)
Ankush, B. P.; Shitole, B. V.; Shitole, N. V. The Green and Efficient One-Pot Synthesis of Tetrahydrobenzo[b]pyran Derivatives. Orbital: Electron. J. Chem. 2023, 15 (3), 148-152. https://doi.org/10.17807/orbital.v15i3.17906.
Abstract
Glutamic acid is used as an efficient organocatalyst for one-pot synthesis of tetrahydrobenzo [b]pyran via condensation of an aromatic aldehyde, dimedone and malononitrile in ethanol: water (1:4) as solvent at reflux temperature. The short reaction time, cleaner reaction, and easy workup make this protocol practical and economically attractive.
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