Orbital - Vol. 12 No. 3 - July-September 2020

Antiprotozoal Activity of Xanthone Derivatives

Ana Camila Micheletti
Universidade Federal de Mato Grosso do Sul
Neli Kika Honda
Universidade Federal de Mato Grosso do Sul
Paola Dias de Oliveira
Universidade Federal de Mato Grosso do Sul
Dênis Pires de Lima
Universidade Federal de Mato Grosso do Sul
Adilson Beatriz
Universidade Federal de Mato Grosso do Sul
Sérgio de Albuquerque
Universidade de São Paulo - USP-RP
Published September 30, 2020
  • lichen,
  • Leishmania spp,
  • structural modification,
  • Trypanosoma cruzi,
  • xanthone
How to Cite
Micheletti, A. C.; Honda, N. K.; de Oliveira, P. D.; de Lima, D. P.; Beatriz, A.; de Albuquerque, S. Antiprotozoal Activity of Xanthone Derivatives. Orbital: Electron. J. Chem. 2020, 12, 127-132.


A series of xanthone derivatives containing different side chains, including ω-bromo and ω-aminoalkoxylxanthones (with linear alkoxy chains of 3, 4 and 5 carbon atoms and methyl, propyl, tert-butylamino and piperidinyl moieties), synthesized from the natural xanthone lichexanthone were tested for their antiprotozoal activities against Leishamania braziliensisL. major and Trypanosoma cruzi (extra and intracellular forms). The ω-aminoalkoxylxanthones showed good antileishmanial activity, with IC50 ranging from 62.8 to 0.1 µM for promastigotes and 119.3 to 2.4 µM for amastigotes. In general, compounds with longer alkyl chains and tert-butylamino moiety showed better activity. The cytotoxicity on VERO cells was also described for some derivatives. Compound 15 (tert-butylaminobutyloxy side chain) was the most active on promastigote forms (IC50 0.1 µM), compound 16 (tert-butylaminopentyloxy side chain) sowed the best activity for amastigotes (IC50 2.4 µM) and derivative 13 (dipropylaminopentyloxy side chain) was the most selective (selectivity index of 9.4). Regarding trypanocidal activity, 16 and other groups of derivatives, (ω-bromoalkoxylxanthones, prenyl and epoxyl side chains) had moderate to good activity on T. cruzi trypomastigotes, with IC50 ranging from 30.6 to 4.1 µM, while only two ω-aminoalkoxylxanthones (10 and 11) were weakly active against T. cruzi amastigotes.

DOI: http://dx.doi.org/10.17807/orbital.v12i3.1460