Orbital - Vol. 14 No. 4 - October-December 2022
REVIEWS

Natural Products and Synthetic Derivatives as Promising Candidates Against Neglected Tropical Diseases

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  • Ana Flávia dos Santos Fuzaro,
  • Carolina Sousa Ponciano,
  • José C. Barros,
  • Richard M. Grazul,
  • Mauro Vieira de Almeida,
  • Eloah Pereira Ávila
Ana Flávia dos Santos Fuzaro
Departamento de Química, Universidade Federal de Juiz de Fora, São Pedro, Juiz de Fora - MG, 36036-900, Brazil
Carolina Sousa Ponciano
Departamento de Química, Universidade Federal de Juiz de Fora, São Pedro, Juiz de Fora - MG, 36036-900, Brazil
José C. Barros
Instituto de Química, Universidade Federal do Rio de Janeiro. Avenida Athos da Silveira Ramos, 149, Cidade Universitária, Rio de Janeiro - RJ, 21941-909, Brazil.
Richard M. Grazul
Departamento de Química, Universidade Federal de Juiz de Fora, São Pedro, Juiz de Fora - MG, 36036-900, Brazil
Mauro Vieira de Almeida
Departamento de Química, Universidade Federal de Juiz de Fora, São Pedro, Juiz de Fora - MG, 36036-900, Brazil
Eloah Pereira Ávila
Departamento de Química, Universidade Federal de Juiz de Fora, São Pedro, Juiz de Fora - MG, 36036-900, Brazil
DOI: https://doi.org/10.17807/orbital.v14i4.16374
Published December 28, 2022
Keywords
  • Chagas Disease,
  • Leishmaniasis,
  • Natural products,
  • Neglected Tropical Diseases – NTD,
  • Trypanosomiasis
How to Cite
(1)
dos Santos Fuzaro, A. F.; Sousa Ponciano, C.; Barros, J. C.; M. Grazul, R.; Vieira de Almeida, M.; Pereira Ávila, E. Natural Products and Synthetic Derivatives As Promising Candidates Against Neglected Tropical Diseases. Orbital: Electron. J. Chem. 2022, 14, 247-266.

Copyright (c) 2022 Orbital: The Electronic Journal of Chemistry

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Abstract

Neglected Tropical Diseases (NTD) are a group of endemic diseases that cause up to one million deaths annually. Leishmaniasis and Chagas Disease are classified as NTD whose current treatments are of limited access. There is an urgent need to develop new agents to combat or alleviate the symptoms of these pathologies. The present work highlights the activities of several natural products and their derivatives which have been tested against the causative parasites of both diseases. The activities of natural products illustrate their potential to assist in the combat against NTD. Research in this area could provide an opportunity to advance medical research and to provide treatments to low- and middle-income countries.

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