Cu(OH)x: Clay Catalyst Promoted Synthesis of 4,5-dihydro-1,2,4-oxadiazole at Room Temperature
Bashir Ahmad Dar- Zahed Zaheer
- green chemistry,
- cycloaddition,
- heterogeneous catalyst,
- oxadiazoles,
- imines
Copyright (c) 2017 Orbital: The Electronic Journal of Chemistry
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Abstract
An easy and efficient scheme is described designed for the preparation of 4,5-dihydro-1,2,4-oxadiazole using recyclable Cu(OH)x-Clay heterogeneous catalyst at room temperature. The cyclo-addition reaction is carried out between imine and oxime using an easy protocol where nitrile oxides are produced in-situ from aldoximes and reacted with imines to construct 1,2,4-oxadiazolines in good yield and tremendous purity. Cu(OH)x-Clay catalyst shows excellent catalytic activity for the formation of 1,2,4-oxadiazole. The technique is practically uncomplicated, inexpensive, and excellent with wide range of functional group tolerance to generate structurally different 1,2,4-oxadiazoles. The prepared catalyst was investigated by XRD and SEM techniques. The final products of synthesized compound were characterized by FTIR, NMR spectroscopy and mass spectrometry.