Orbital - Vol. 8 No. 3 - April - June 2016
FULL PAPERS

Square-Wave Voltammetric Determination of Antihistaminic Drug Hydroxyzine in Pharmaceuticals Using a Boron-doped Diamond Electrode

Jessica Scremin
Universidade Estadual de Londrina
Elen Romão Sartori
Universidade Estadual de Londrina
Published June 30, 2016
Keywords
  • hydroxyzine determination,
  • boron-doped diamond electrode,
  • cathodic pretreatment,
  • antihistaminic drug,
  • pharmaceutical formulations
How to Cite
(1)
Scremin, J.; Sartori, E. R. Square-Wave Voltammetric Determination of Antihistaminic Drug Hydroxyzine in Pharmaceuticals Using a Boron-Doped Diamond Electrode. Orbital: Electron. J. Chem. 2016, 8, 174-180.

Abstract

The determination of antihistaminic hydroxyzine using square-wave voltammetry and a cathodically pretreated boron-doped diamond electrode is described. The obtained analytical curve was linear in the hydroxyzine concentration range 0.50 – 20.0 mmol L1 in 0.1 mol L–1 HCl solution, with a detection limit of 0.43 mmol L1. Addition and recovery studies in commercial tables and liquid formulations showed excellent recovery values ranging from 94.3 % to 104 %. Furthermore, the proposed method was successfully applied in the determination of hydroxyzine in several pharmaceutical formulations and the results were in a close agreement at a 95 % confidence level with those obtained using an official potentiometric method.

DOI: http://dx.doi.org/10.17807/orbital.v8i3.833