Advances in Multicomponent Petasis Reaction: A 2020-2025 Review

Abstract

The Petasis–Boronic multicomponent reaction has emerged as a practical and versatile method for building structurally complex molecules, particularly frameworks bearing newly formed stereocenters. Known for its operational simplicity, mild conditions, and broad functional-group tolerance, it offers an attractive alternative to classical Mannich-type processes. Over time, its scope has expanded through advances that improve stereocontrol, substrate diversity, and reaction efficiency. Over the years, its scope has broadened with developments that enhance stereocontrol, functional group compatibility, and overall efficiency. Recent progress, including asymmetric variants, photoredox-mediated strategies, and continuous-flow adaptations, underscores the flexibility of this transformation. The use of novel boronic acid derivatives and unconventional substrates has further expanded its synthetic potential, enabling the rapid construction of complex molecular frameworks. Collectively, these advances establish the Petasis reaction as a dynamic platform in modern multicomponent chemistry, with wide applicability.