Orbital - Vol. 8 No. 3 - April - June 2016
SHORT COMMUNICATIONS

Microwave Assisted Synthesis of Some Novel Series of 4-Thiazolidinone Derivatives as Potent Antimicrobial Analogs

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  • Sainath Zangade,
  • Avinash Shinde,
  • Yogesh Nalwar,
  • Yeshwant Vibhute
Sainath Zangade
Department of Chemistry, Madhavrao Patil College, Palam Dist. Parbhani
Avinash Shinde
Department of Chemistry, N.E.S. Science College
Yogesh Nalwar
Department of Chemistry, Toshniwal ACS College, Sengaon
Yeshwant Vibhute
Organic Research Center, Department of Chemistry Yeshwant Mahavidyalaya
Published June 30, 2016
Keywords
  • 4-thiazolidinones,
  • halogenohydroxy Schiff bases,
  • microwave irradiation,
  • antimicrobial activity
How to Cite
(1)
Zangade, S.; Shinde, A.; Nalwar, Y.; Vibhute, Y. Microwave Assisted Synthesis of Some Novel Series of 4-Thiazolidinone Derivatives As Potent Antimicrobial Analogs. Orbital: Electron. J. Chem. 2016, 8, 211-217.

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Abstract

Several substituted 4‐thiazolidinone derivatives 2a‐q have been synthesized from halogenohydroxy substituted Schiff bases 1a-q under microwave irradiation technique. The reactions were carried out using ethanol: 2-methoxyethanol mixture as efficient reaction solvent system to afford high yield of product. The structures of newly synthesized compounds have been established on the basis of elemental analysis, IR, 1H & 13C NMR and mass spectral data. Further, all newly synthesized compounds were screened for their in vitro antimicrobial activity. The antifungal and antibacterial effects of the tested compounds are due to their molecular structure and substituent present.

DOI: http://dx.doi.org/10.17807/orbital.v8i3.838

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