Orbital - Vol. 16 No. 4 - October-December 2024
FULL PAPERS

Cytotoxicity of Alkyl Derivatives of Protocetraric Acid

PDF
  • Danielle Bogo,
  • Glaucia Braz Alcantara,
  • Ana Camila Micheletti,
  • Neli Kika Honda,
  • Maria de Fátima Cepa Matos
Danielle Bogo
UFMS
Glaucia Braz Alcantara
UFMS
Ana Camila Micheletti
Department of Chemistry, UFMS
Neli Kika Honda
UFMS
Maria de Fátima Cepa Matos
UFMS
DOI: https://doi.org/10.17807/orbital.v16i4.21887
Published January 7, 2025
Keywords
  • alkyl derivatives,
  • depsidone,
  • lichens,
  • protocetraric acid,
  • toxicity,
  • tumor cells
    • ...More
    Less
How to Cite
(1)
Bogo, D.; Alcantara, G.; Camila Micheletti, A.; Honda, N.; Cepa Matos, M. de F. Cytotoxicity of Alkyl Derivatives of Protocetraric Acid. Orbital: Electron. J. Chem. 2025, 16, 267-270.

Copyright (c) 2025 Orbital: The Electronic Journal of Chemistry

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Crossref
Scopus
Google Scholar
Europe PMC

Abstract

The protocetraric acid (1) is a depsidone produced by countless species of lichens and has shown potential biological activity. In this work, we evaluated through the sulforhodamine B (SRB) assay the cytotoxic activity of seven alkyl ether derivatives of protocetraric acid (9´-O-alkyl protocetraric acid) against the following cell lines: HT-29 (colon carcinoma), 786-0 (kidney carcinoma), MCF7 (breast carcinoma), HEP2 (laryngeal carcinoma), PC-03 (prostate carcinoma), B16F10 (murine melanoma), UACC-62 (human melanoma), and NIH/3T3 (mouse embryonic fibroblast).  Most compounds were cytotoxic to tested cells, with GI50 < 100.0 μM, and did not show selectivity over them.

PDF