Orbital - Vol. 10 No. 7 - October-December 2018
FULL PAPERS

Synthesis and Antimicrobial Activity of 4-S-Methyl-1,3,4-Oxadiazole Derivatives of Some Natural Amino Acids Bearing Secondary Quaternary Ammonium Salt Moieties

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  • Daoudi Sofiane,
  • Ali Othman Adil,
  • Benaissa Tahar,
  • Adli Djallal Eddine
Daoudi Sofiane
Laboratoire de Chimie Organique Bioactive, Département de Chimie Organique Industrielle, Faculté de Chimie, Université des Sciences et de la Technologie d’Oran- Mohamed Boudiaf
Ali Othman Adil
Département de Chimie Organique Industrielle, Faculté de Chimie, Université des Sciences et de la Technologie d’Oran
Benaissa Tahar
Laboratoire étude physiquo-chimique, Université Dr. Moulay Tahar
Adli Djallal Eddine
Laboratoire de Biotoxicologie, Pharmacognosie et Valorisation Biologiques des Plantes, Université Dr. Moulay
Published December 25, 2018
Keywords
  • amino acid,
  • quaternary ammonium salts,
  • 1,3,4-oxadiazole,
  • antimicrobial activity
How to Cite
(1)
Sofiane, D.; Adil, A. O.; Tahar, B.; Eddine, A. D. Synthesis and Antimicrobial Activity of 4-S-Methyl-1,3,4-Oxadiazole Derivatives of Some Natural Amino Acids Bearing Secondary Quaternary Ammonium Salt Moieties. Orbital: Electron. J. Chem. 2018, 10, 482-488.

Copyright (c) 2018 Orbital: The Electronic Journal of Chemistry

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Abstract

Secondary quaternary ammonium salts (QAS) derived from three natural amino acids (L-Leucine, L-Phenylalanine and L-Methionine) bearing 1,3,4-oxadiazole and acetic acid moieties have been synthesized and characterized by IR, 1H and 13C NMR. All the synthesized compounds were evaluated for their preliminary in vitro antibacterial and antifungal activity against different bacterial and fungal strains. All the synthesized compounds showed varying degrees of inhibition against the tested microorganisms.

DOI: http://dx.doi.org/10.17807/orbital.v10i7.990

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