Orbital - Vol. 7 No. 2 - April-June 2015
FULL PAPERS

Comparative Antibacterial Activities of Some Monosaccharide and Disaccharide Benzoates

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  • Mohammed M. Matin,
  • Mohammed H. Bhuiyan,
  • Mohammed Manir Hossain,
  • Mohammad Harun Or Roshid
Mohammed M. Matin
Department of Chemistry, University of Chittagong
Mohammed H. Bhuiyan
Department of Chemistry, University of Chittagong
Mohammed Manir Hossain
Department of Chemistry, University of Chittagong
Mohammad Harun Or Roshid
Department of Anesthesia and Intensive Care, Chittagong Medical College
Published June 28, 2015
Keywords
  • monosaccharides,
  • rhamnopyranoside,
  • benzoylation,
  • antibacterial activity,
  • structure activity relationship (SAR)
How to Cite
(1)
Matin, M. M.; Bhuiyan, M. H.; Hossain, M. M.; Or Roshid, M. H. Comparative Antibacterial Activities of Some Monosaccharide and Disaccharide Benzoates. Orbital: Electron. J. Chem. 2015, 7, 160-167.

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Abstract

For comparative antibacterial studies a number of furanose (3, 5), pyranose (7, 9, 11, 13), and disaccharide benzoates (14, 15) were prepared by direct benzoylation method. Synthesized benzoates (3, 5, 7, 9, 11, 13-15) along with some starting materials were screened for in vitro antibacterial activity against ten human pathogenic bacteria viz. Bacillus subtilis, Bacillus cereus, Bacillus megaterium, Staphylococcus aureus, Escherichia coli, INABA ET (Vibrio), Pseudomonas species, Salmonella paratyphi, Salmonella typhi, and Shigella dysenteriae. The study revealed that the pyranose benzoate derivatives (7, 9, 11, 13) were more prone towards antibacterial functionality than that of the furanose benzoate (3, 5) and disaccharide benzoates (14, 15).

DOI: http://dx.doi.org/10.17807/orbital.v7i2.699

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